A modular approach for the construction and modification of glyco-SAMs utilizing 1,3-dipolar cycloaddition

被引：37

作者：

Kleinert, Mike ^{[2
]}

Winkler, Tobias ^{[1
]}

Terfort, Andreas ^{[1
]}

Lindhorst, Thisbe K. ^{[2
]}

机构：

[1] Univ Marburg, Dept Chem, D-35032 Marburg, Germany

[2] Univ Kiel, Otto Diels Inst Organ Chem, D-24098 Kiel, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 12期

关键词：

D O I：

10.1039/b801595c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the synthesis of a broad variety of functionalized molecules for assembly on gold, allowing the formation of biologically relevant SAMs by a modular approach: either utilizing 1,3-dipolar cycloaddition of alkynes and azides in solution or by 'click on SAM'. Extensive studies into the various parameters of SAM formation and stability have been carried out, leading us to deduce reliable conditions under which glyco-decorated self-assembled monolayers can be formed and studied such as in SPR-supported binding assays.

引用

页码：2118 / 2132

页数：15

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