Adhesion signaling:: How β-catenin interacts with its partners

被引:183
作者
Gottardi, CJ [1 ]
Gumbiner, BM [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA
关键词
D O I
10.1016/S0960-9822(01)00473-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The multi-functional protein beta -catenin plays essential roles in cell-cell adhesion and nuclear signaling. Elucidation of the structures of beta -catenin complexes is beginning to clarify how beta -catenin uses the same surface to bind its various partners, and provides insights into how these interactions might be regulated. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:R792 / R794
页数:3
相关论文
共 20 条
  • [1] p120ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells
    Aono, S
    Nakagawa, S
    Reynolds, AB
    Takeichi, M
    [J]. JOURNAL OF CELL BIOLOGY, 1999, 145 (03) : 551 - 562
  • [2] Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus
    Fagotto, F
    Funayama, N
    Gluck, U
    Gumbiner, BM
    [J]. JOURNAL OF CELL BIOLOGY, 1996, 132 (06) : 1105 - 1114
  • [3] E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner
    Gottardi, CJ
    Wong, E
    Gumbiner, BM
    [J]. JOURNAL OF CELL BIOLOGY, 2001, 153 (05) : 1049 - 1059
  • [4] Crystal structure of a β-catenin/Tcf complex
    Graham, TA
    Weaver, C
    Mao, F
    Kimelman, D
    Xu, WQ
    [J]. CELL, 2000, 103 (06) : 885 - 896
  • [5] Regulation of cadherin adhesive activity
    Gumbiner, BM
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 148 (03) : 399 - 403
  • [6] Three-dimensional structure of the armadillo repeat region of beta-catenin
    Huber, AH
    Nelson, WJ
    Weis, WI
    [J]. CELL, 1997, 90 (05) : 871 - 882
  • [7] The structure of the β-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by β-catenin
    Huber, AH
    Weis, WI
    [J]. CELL, 2001, 105 (03) : 391 - 402
  • [8] E-CADHERIN AND APC COMPETE FOR THE INTERACTION WITH BETA-CATENIN AND THE CYTOSKELETON
    HULSKEN, J
    BIRCHMEIER, W
    BEHRENS, J
    [J]. JOURNAL OF CELL BIOLOGY, 1994, 127 (06) : 2061 - 2069
  • [9] Casein kinase II phosphorylation of E-cadherin increases E-cadherin/β-catenin interaction and strengthens cell-cell adhesion
    Lickert, H
    Bauer, A
    Kemler, R
    Stappert, J
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (07) : 5090 - 5095
  • [10] MCCREA PD, 1991, J BIOL CHEM, V266, P4514