Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

被引：118

作者：

Li, Ruibin ^{[1
]}

Wu, Ren'an ^{[1
]}

Zhao, Liang ^{[1
]}

Hu, Zhengyan ^{[1
]}

Guo, Shujing ^{[2
]}

Pan, Xiulian ^{[2
]}

Zou, Hanfa ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

来源：

CARBON | 2011年 / 49卷 / 05期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

CORE-SHELL NANOPARTICLES; INTRACELLULAR DELIVERY; CONTROLLED-RELEASE; FUNCTIONALIZATION; TRANSPORTERS; DESIGN; BIOAPPLICATIONS; DOXORUBICIN; DISCOVERY; THERAPY;

D O I：

10.1016/j.carbon.2011.01.003

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A nanomaterial, folate and iron difunctionalized multiwall carbon nanotube (FA-MWCNT@Fe), has been synthesized by conjugating folate and iron nanoparticles with oxidized multi-walled carbon nanotubes, and applied as a dual-targeted drug nanocarrier to deliver doxorubicin into HeLa cells with the assistance of an external magnetic field. The prepared FA-MWCNT@Fe was characterized by X-ray diffraction, transmission electron microscopy and infrared spectroscopy. This nanocarrier has a sufficient load capacity (doxorubicin/FA-MWCNT@Fe, 32 mu g/mg) and a prolonged release property controlled by near infrared radiation. It also demonstrated both biologically (active) and magnetically (passive) targeting capabilities toward HeLa cells in vitro with ca. 6-fold higher delivery efficiency of doxorubicin than free doxorubicin. (C) 2011 Elsevier Ltd. All rights reserved.

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页码：1797 / 1805

页数：9

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