Untranslated region haplotype in dysbindin gene: analysis in schizophrenia

被引:12
作者
De Luca, V
Voineskos, D
Shinkai, T
Wong, G
Kennedy, JL
机构
[1] Univ Toronto, Ctr Addict & Mental Hlth, Neurogenet Sect, Dept Psychiat, Toronto, ON M5T 1R8, Canada
[2] Univ Naples Federico II, Dept Neurosci, Sect Psychiat, Naples, Italy
[3] Univ Occupat & Environm Hlth, Dept Psychiat, Kitakyushu, Fukuoka 807, Japan
关键词
polymorphism; TRANSMIT; FBAT; genetics; schizophrenia; DTNBP1;
D O I
10.1007/s00702-005-0338-9
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Genome-scans performed in schizophrenia families have provided evidence for region 6p24-21 where variability may confer susceptibility to schizophrenia. Recent studies have implicated that gene DTNBP1 (dysbindin) in this region is strongly associated with schizophrenia. In a family based association study we investigated three markers located in the untranslated region of the DTNBP1 gene: rs909706, rs1047631 and rs742106. The sample size of our study is 117 families. No biased transmission towards the disorder was detected by haplotype analysis using TRANSMIT.
引用
收藏
页码:1263 / 1267
页数:5
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