The origins of medulloblastoma subtypes

被引：206

作者：

Gilbertson, Richard J. ^{[1
,2
]}

Ellison, David W. ^{[3
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2008年 / 3卷

关键词：

PNET; cancer stem cell; development; cerebellum;

D O I：

10.1146/annurev.pathmechdis.3.121806.151518

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Childhood tumors containing cells that are morphologically and functionally similar to normal progenitor cells provide fertile ground for investigating the links between development and cancer. In this respect, integrated studies of normal cerebellar development and the medulloblastoma, a malignant embryonal tumor of the cerebellum, have proven especially fruitful. Emerging evidence indicates that the different precursor cell populations that form the cerebellum and the cell signaling pathways that regulate its development likely represent distinct compartments from which the various sub-types of medulloblastoma arise. Definitive characterization of each medulloblastoma subtype will undoubtedly improve treatment of this disease and provide important insights to the origins of cancer.

引用

页码：341 / 365

页数：25

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