Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxide

被引：33

作者：

Cooper, CE ^{[1
]}

机构：

[1] Univ Essex, Dept Biol Sci, Colchester CO4 3SQ, Essex, England

来源：

IUBMB LIFE | 2003年 / 55卷 / 10-11期

关键词：

nitric oxide; peroxynitrite; mitochondria; cytochrome oxidase; inhibition; cytochrome c oxidase; oxygen; K-m;

D O I：

10.1080/15216540310001628663

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the mid 1990s a number of research groups recognized that mitochondrial oxygen consumption could be reversibly inhibited by nitric oxide at the level of the enzyme cytochrome c oxidase. The inhibition was apparently competitive with respect to the oxygen concentration. This review critically assesses the present state of knowledge as regards the hypothesis that nitric oxide is a competitive, reversible, physiological inhibitor of cytochrome oxidase.

引用

页码：591 / 597

页数：7

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