The role of HIF-1α in myeloid cell inflammation

被引：68

作者：

Walmsley, SR

Cadwallader, KA

Chilvers, ER ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Dept Med, Div Resp Med,Addenbrookes Hosp, Cambridge CB2 2QQ, England

[2] Univ Cambridge, Sch Clin Med, Dept Med, Div Resp Med,Papworth Hosp, Cambridge CB2 2QQ, England

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 08期

关键词：

D O I：

10.1016/j.it.2005.06.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid cells are key effectors of the innate immune response, and as such are often required to migrate to, and function within, sites that are markedly hypoxic. To adapt to such oxygen deplete environments they have developed functional and survival responses that are regulated by the hypoxia-inducible factor (HIF) oxygen-sensing pathway. In this review, we describe three key aspects of HIF-dependent regulation of myeloid cell function: (i) the maintenance of ATP pools and the subsequent regulation of proinflammatory responses, (ii) the HIF-dependent inhibition of neutrophil apoptosis and (iii) the HIF-mediated regulation beta 2 integrin expression.

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页码：434 / 439

页数：6

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