Granzyme B: a marker of risk for influenza in institutionalized older adults

被引：38

作者：

McElhaney, JE

Gravenstein, S

Upshaw, CM

Hooton, JW

Krause, P

Drinka, P

Bleackley, RC

机构：

[1] Eastern Virginia Med Sch, Glennan Ctr Geriatr & Gerontol, Norfolk, VA 23507 USA

[2] Univ Alberta, Dept Med, Edmonton, AB T6G 2R7, Canada

[3] Wisconsin Vet Home, King, WI 54946 USA

[4] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

来源：

VACCINE | 2001年 / 19卷 / 27期

关键词：

granzyme B; influenza; older adults;

D O I：

10.1016/S0264-410X(01)00087-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Risk for influenza increases with age while cellular immune responses decline. This was a prospective study to determine the relationship between cytokine and granzyme B levels in peripheral blood mononuclear cells stimulated with live influenza virus, and subsequent influenza illness. Granzyme B levels were lower in the group who later developed symptomatic laboratory-confirmed influenza (n = 10) compared to the group who did not (n = 90) (ANOVA, P = 0.024). In contrast, none of the cytokine levels were related to the development of influenza. Thus, granzyme B is a potential marker of influenza risk in older adults. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3744 / 3751

页数：8

共 31 条

[1] REDUCTION IN MORTALITY ASSOCIATED WITH INFLUENZA VACCINE DURING 1989-90 EPIDEMIC [J].