Potential dietary exposure to p-nonylphenol from food-contact use of tris(nonylphenyl)phosphite (TNPP)

被引:16
作者
Howe, SR
Surana, P
Jakupca, MR
Borodinsky, L
机构
[1] Soc Plast Ind Inc, Washington, DC 20006 USA
[2] GE Plast, Pittsfield, MA 01201 USA
[3] Keller & Heckman LLP, Washington, DC USA
来源
FOOD ADDITIVES AND CONTAMINANTS | 2001年 / 18卷 / 11期
关键词
TNPP; food-contact materials; migration data; LLDPE;
D O I
10.1080/02652030110050320
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The potential exposure to p-nonylphenol from the use of tris( nonylphenyl) phosphite (TNPP) in food-contact materials was calculated. The calculation was made on the basis of migration data from moulded plaques prepared from linear low-density polyethylene (LLDPE), films prepared from LLDPE and polyvinyl chloride (PVC) films. The data were obtained using the customary experimental procedures developed by the US Food and Drug Administration (FDA). The potential migration of p-nonylphenol to food from the use of TNPP as a component of food-contact articles was determined using food-simulating solvents and time and temperature conditions recommended by the FDA. Using the data obtained from these studies, along with procedures based on the FDA's conventional method for estimating potential dietary exposure using food simulating migration data, the potential dietary exposure to p-nonylphenol from the use of TNPP was determined to be similar to 25.5 parts per billion (ppb). Because the conditions of the migration tests exaggerate actual use conditions, this value overstates the potential dietary exposure.
引用
收藏
页码:1021 / 1039
页数:19
相关论文
共 12 条
[1]  
Crank J, 1979, MATH DIFFUSION
[2]  
*FDA, 2000, GUID IND PREP PREM N
[3]  
FDA, 1995, REC CHEM DAT IND FOO
[4]  
*FDA, 1993, REC CHEM DAT IND FOO
[5]   A MODEL FOR ESTIMATING THE DAILY DIETARY-INTAKE OF A SUBSTANCE FROM FOOD-CONTACT ARTICLES - STYRENE FROM POLYSTYRENE FOOD-CONTACT POLYMERS [J].
LICKLY, TD ;
BREDER, CV ;
RAINEY, ML .
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 1995, 21 (03) :406-417
[6]  
LICKLY TD, 1993, SAFETY STYRENE BASED
[7]  
*SOC PLAST IND INC, 1995, FOOD DRUG COSM PACK
[8]  
1998, MODERN PLASTICS, P74
[9]  
1994, MODERN PLASTICS, P75
[10]  
1995, MODERN PLASTICS, P65