Morphine withdrawal increases expression of GABAA receptor ε subunit mRNA in locus coeruleus neurons

被引：19

作者：

Heikkilä, AT ^{[1
]}

Echenko, O ^{[1
]}

Uusi-Oukari, M ^{[1
]}

Sinkkonen, ST ^{[1
]}

Korpi, ER ^{[1
]}

机构：

[1] Univ Turku, Dept Pharmacol & Clin Pharmacol, FIN-20520 Turku, Finland

来源：

NEUROREPORT | 2001年 / 12卷 / 13期

关键词：

GABA(A) receptor subunits; in situ hybridisation; morphine; opiate withdrawal;

D O I：

10.1097/00001756-200109170-00045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An increase in the activity of brain stem locus coeruleus noradrenergic neurons has been hypothesised to be a major factor accounting for opiate withdrawal symptoms. These neurons are under GABAergic inhibition. Their GABA(A) receptors have unique pharmacological properties, most likely due to the enriched expression of GABA(A) receptor subtypes containing novel epsilon and theta subunits. Using in situ hybridisation of cryostat sections, we now report a significant increase in the e subunit mRNA expression after precipitation of opioid withdrawal by naloxone. Similar changes were detected in tyrosine hydroxylase mRNA expression. The results suggest increased formation of unique GABA(A) receptor subtype(s) in the locus coeruleus neurons during increased neuronal activity. NeuroReport 12:2981-2985 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：2981 / 2985

页数：5

共 24 条

[1]

ASTONJONES G, 1991, PROG BRAIN RES, V88, P47

[2]

Barnard EA, 1998, PHARMACOL REV, V50, P291

[3] θ, a novel γ-aminobutyric acid type A receptor subunit [J].

Bonnert, TP ;

McKernan, RM ;

Farrar, S ;

le Bourdellès, B ;

Heavens, RP ;

Smith, DW ;

Hewson, L ;

Rigby, MR ;

Sirinathsinghji, DJS ;

Brown, N ;

Wafford, KA ;

Whiting, PJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) :9891-9896

[4] Activation of rat locus coeruleus neuron GABAA receptors by propofol and its potentiation by pentobarbital or alphaxalone [J].

Chen, CL ;

Yang, YR ;

Chiu, TH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 386 (2-3) :201-210

[5] THE CONCEPTS OF STRESS AND STRESS SYSTEM DISORDERS - OVERVIEW OF PHYSICAL AND BEHAVIORAL HOMEOSTASIS [J].

CHROUSOS, GP ;

GOLD, PW .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1992, 267 (09) :1244-1252

[6] Noradrenergically mediated plasticity in a human attentional neuronal network [J].

Coull, JT ;

Büchel, C ;

Friston, KJ ;

Frith, CD .

NEUROIMAGE, 1999, 10 (06) :705-715

[7] LOFEXIDINE AND OPIOID WITHDRAWAL [J].

COX, S ;

ALCORN, R .

LANCET, 1995, 345 (8962) :1385-1386

[8]

HARRIS GC, 1992, J PHARMACOL EXP THER, V261, P476

[9] The diversity of GABAA receptors -: Pharmacological and electrophysiological properties of GABAA channel subtypes [J].

Hevers, W ;

Lüddens, H .

MOLECULAR NEUROBIOLOGY, 1998, 18 (01) :35-86

[10] IMMUNOCYTOCHEMICAL AND INSITU HYBRIDIZATION EVIDENCE FOR THE COEXISTENCE OF GABA AND TYROSINE-HYDROXYLASE IN THE RAT LOCUS-CERULEUS [J].

IIJIMA, K ;

SATO, M ;

KOJIMA, N ;

OHTOMO, K .

ANATOMICAL RECORD, 1992, 234 (04) :593-604

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