Alternative methods for the MnO2 oxidation of codeine methyl ether to thebaine utilizing ionic liquids

被引：33

作者：

Singer, RD ^{[1
]}

Scammells, PJ

机构：

[1] St Marys Univ, Dept Chem, Halifax, NS B3H 3C3, Canada

[2] Deakin Univ, Ctr Chiral & Mol Technol, Geelong, Vic 3217, Australia

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 39期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)01383-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The MnO2 oxidation of codeine methyl ether, CME, to thebaine has been accomplished via the use of the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate, bmimBF(4). The ionic liquid has been used to remove or extract excess MnO2, and associated impurities from the reaction mixture to afford thebaine in 36 to > 95% yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6831 / 6833

页数：3

共 14 条

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