Human chorionic gonadotrophin (hCG) enhances immunity against L. tropica by stimulating human macrophage functions

被引：7

作者：

Abu Alshamat, E. ^{[1
]}

Al-Okla, S. ^{[1
]}

Soukkarieh, C. H. ^{[1
]}

Kweider, M. ^{[1
]}

机构：

[1] Damascus Univ, Immunol Lab, Dept Anim Biol, Fac Sci, Damascus, Syria

来源：

PARASITE IMMUNOLOGY | 2012年 / 34卷 / 10期

关键词：

cytotoxicity activity; hCG; immune responses; Leishmania; macrophage; sex-associated hormones; NITRIC-OXIDE; INTERFERON-GAMMA; INTERLEUKIN-12; RESISTANCE; RECEPTORS; PREGNANCY; CYTOKINES; CELLS; LEISHMANIASIS; ACTIVATION;

D O I：

10.1111/j.1365-3024.2012.01368.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During pregnancy, there are important changes in hormone levels such as the huge production of human chorionic gonadotropin (hCG), which is supposed to influence the immune system. The aim of this study was to investigate the effect of hCG on immune response against Leishmania, through the evaluation of the functions of human macrophages infected with L. tropica. This study demonstrated that hCG significantly increased the NO production by rHu-IFN?-primed macrophages then infected with L. tropica, which was correlated with decrease in the number of infected macrophages as well as the number of amastigotes per macrophage in a dose-dependent manner; however, the greatest effect was shown with the 250 U/mL concentration. The addition of the same concentration of hCG to rHu-IFN gamma-primed macrophages caused also a major increase in both IL-6 and IL-12p40 production. In conclusion, hCG enhances different macrophage functions involved in immunity against L. tropica.

引用

页码：449 / 454

页数：6

共 29 条

[1]

[Anonymous], 2002, WORLD HLTH REP, P192

[2] Functional testosterone receptors in plasma membranes of T cells [J].

Benten, WPM ;

Lieberherr, M ;

Giese, G ;

Wrehlke, C ;

Stamm, O ;

Sekeris, CE ;

Mossmann, H ;

Wunderlich, F .

FASEB JOURNAL, 1999, 13 (01) :123-133

[3] EFFECTS OF IL-12 ON IMMUNE-RESPONSES TO MICROBIAL INFECTIONS - A KEY MEDIATOR IN REGULATING DISEASE OUTCOME [J].

BIRON, CA ;

GAZZINELLI, RT .

CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (04) :485-496

[4] Androgen and estrogen receptors are present in primary cultures of human synovial macrophages [J].

Cutolo, M ;

Accardo, S ;

Villaggio, B ;

Barone, A ;

Sulli, A ;

Coviello, DA ;

Carabbio, C ;

Felli, L ;

Miceli, D ;

Farruggio, R ;

Carruba, G ;

Castagnetta, L .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (02) :820-827

[5] SPECIFIC ESTROGEN BINDING-SITES IN HUMAN LYMPHOID-CELLS AND THYMIC CELLS [J].

DANEL, L ;

SOUWEINE, G ;

MONIER, JC ;

SAEZ, S .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1983, 18 (05) :559-563

[6] Leishmaniasis: current situation and new perspectives [J].

Desjeux, P .

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, 2004, 27 (05) :305-318

[7] INTERLEUKIN-12 IS REQUIRED FOR THE T-LYMPHOCYTE-INDEPENDENT INDUCTION OF INTERFERON-GAMMA BY AN INTRACELLULAR PARASITE AND INDUCES RESISTANCE IN T-CELL-DEFICIENT HOSTS [J].

GAZZINELLI, RT ;

HIENY, S ;

WYNN, TA ;

WOLF, S ;

SHER, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :6115-6119

[8] Alternative activation of macrophages [J].

Gordon, S .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (01) :23-35

[9] Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors [J].

Jones, Leigh A. ;

Anthony, Jean-Paul ;

Henriquez, Fiona L. ;

Lyons, Russell E. ;

Nickdel, Mohammad B. ;

Carter, Katharine C. ;

Alexander, James ;

Roberts, Craig W. .

IMMUNOLOGY, 2008, 125 (01) :59-69

[10] The role of hCG in reproductive medicine [J].

Keay, SD ;

Vatish, M ;

Karteris, E ;

Hillhouse, EW ;

Randeva, HS .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2004, 111 (11) :1218-1228

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