Age-related increase in xanthine oxidase activity in human plasma and rat tissues

被引：55

作者：

Aranda, Rafael ^{[2
]}

Domenech, Elena ^{[1
]}

Rus, Ariana Diana ^{[1
,3
]}

Real, Jose T. ^{[4
]}

Sastre, Juan ^{[1
]}

Vina, Jost ^{[1
]}

Pallardo, Federico V. ^{[1
,3
]}

机构：

[1] Univ Valencia, Dept Physiol, E-46010 Valencia, Spain

[2] Univ Valencia, Dept Sports & Phys Educ, E-46010 Valencia, Spain

[3] CIBERER, Bellaterra, Spain

[4] Clin Univ Hosp Valencia, Dept Endocrinol, Valencia, Spain

来源：

FREE RADICAL RESEARCH | 2007年 / 41卷 / 11期

关键词：

oxidative stress; glutathione; xanthine oxidoreductase; superoxide anion; ageing;

D O I：

10.1080/10715760701481461

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

This study assessed the role of xanthine oxidase in vascular ageing. A positive correlation between xanthine oxidase activity and age was found in human plasma. Similar results were found in rat plasma. Xanthine oxidase expression and activity in homogenates from the aortic wall were significantly higher in samples from old rats than in their young counterparts (p < 0.01). In rat skeletal muscle homogenates both xanthine oxidase expression and activity showed a similar age-related profile. Superoxide production by xanthine oxidase in aortic rings was higher in aged rats. Uric acid, the final product of xanthine oxidase has been proposed as a risk factor for coronary heart disease and an independent marker of worse prognosis in patients with moderate-to-severe chronic heart failure. These results give a possible explanation for this correlation and underscore the role of xanthine oxidase in ageing.

引用

页码：1195 / 1200

页数：6

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