From Krebs to clinic: glutamine metabolism to cancer therapy

被引：1691

作者：

Altman, Brian J. ^{[1
,2
,3
]}

Stine, Zachary E. ^{[1
,2
,3
]}

Dang, Chi V. ^{[1
,2
,3
]}

机构：

[1] Univ Penn, Abramson Family Canc Res Inst, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Med, Perelman Sch Med, Div Hematol Oncol, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS CANCER | 2016年 / 16卷 / 10期

基金：

美国国家卫生研究院;

关键词：

CELL LUNG-CANCER; KIDNEY-TYPE GLUTAMINASE; ACUTE LYMPHOBLASTIC-LEUKEMIA; AMMONIA-INDUCED AUTOPHAGY; NOVO PYRIMIDINE SYNTHESIS; ACUTE MYELOID-LEUKEMIA; RAS-TRANSFORMED CELLS; AMINO-ACID; BREAST-CANCER; MAMMALIAN-CELLS;

D O I：

10.1038/nrc.2016.71

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

引用

页码：619 / 634

页数：16

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