Heterogenous migraine aura symptoms correlate with visual cortex functional magnetic resonance imaging responses

被引：44

作者：

Arngrim, Nanna ^{[1
,2
]}

Hougaard, Anders ^{[1
,2
]}

Ahmadi, Khazar ^{[3
]}

Vestergaard, Mark Bitsch ^{[4
]}

Schytz, Henrik Winther ^{[1
,2
]}

Amin, Faisal Mohammad ^{[1
,2
]}

Larsson, Henrik Bo Wiberg ^{[4
]}

Olesen, Jes ^{[1
,2
]}

Hoffmann, Michael B. ^{[3
,5
]}

Ashina, Messoud ^{[1
,2
]}

机构：

[1] Univ Copenhagen, Danish Headache Ctr, Nordre Ringvej 57, DK-2600 Glostrup, Denmark

[2] Univ Copenhagen, Rigshosp Glostrup, Fac Hlth & Med Sci, Dept Neurol, Nordre Ringvej 57, DK-2600 Glostrup, Denmark

[3] Otto von Guericke Univ, Ophthalm Dept, Visual Proc Lab, Magdeburg, Germany

[4] Univ Copenhagen, Dept Clin Physiol Nucl Med & PET, Fac Hlth & Med Sci, Funct Imaging Unit,Rigshosp Glostrup, Glostrup, Denmark

[5] Ctr Behav Brain Sci, Magdeburg, Germany

来源：

ANNALS OF NEUROLOGY | 2017年 / 82卷 / 06期

关键词：

D O I：

10.1002/ana.25096

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

ObjectiveMigraine aura is sparsely studied due to the highly challenging task of capturing patients during aura. Cortical spreading depression (CSD) is likely the underlying phenomenon of aura. The possible correlation between the multifaceted phenomenology of aura symptoms and the effects of CSD on the brain has not been ascertained. MethodsFive migraine patients were studied during various forms of aura symptoms induced by hypoxia, sham hypoxia, or physical exercise with concurrent photostimulation. The blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to visual stimulation was measured in retinotopic mapping-defined visual cortex areas V1 to V4. ResultsWe found reduced BOLD response in patients reporting scotoma and increased response in patients who only experienced positive symptoms. Furthermore, patients with bilateral visual symptoms had corresponding bihemispherical changes in BOLD response. InterpretationThese findings suggest that different aura symptoms reflect different types of cerebral dysfunction, which correspond to specific changes in BOLD signal reactivity. Furthermore, we provide evidence of bilateral CSD recorded by fMRI during bilateral aura symptoms. Ann Neurol 2017;82:925-939

引用

页码：925 / 939

页数：15

共 43 条

[1]

Lashley K.S., Patterns of cerebral integration indicated by the scotomas of migraine, Arch Neurol Psychiatry, 42, pp. 259-264, (1941)

[2]

Hansen J.M., Goadsby P.J., Charles A.C., Variability of clinical features in attacks of migraine with aura, Cephalalgia, 36, pp. 216-224, (2016)

[3]

Hansen J.M., Baca S.M., VanValkenburgh P., Charles A., Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording, Brain, 136, pp. 3589-3595, (2013)

[4]

Russell M.B., Olesen J., A nosographic analysis of the migraine aura in a general population, Brain, 119, pp. 355-361, (1996)

[5]

Queiroz L.P., Friedman D.I., Rapoport A.M., Purdy R.A., Characteristics of migraine visual aura in Southern Brazil and Northern USA, Cephalalgia, 31, pp. 1652-1658, (2011)

[6]

Ayata C., Lauritzen M., Spreading depression, spreading depolarizations, and the cerebral vasculature, Physiol Rev, 95, pp. 953-993, (2015)

[7]

Olesen J., Larsen B., Lauritzen M., Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine, Ann Neurol, 9, pp. 344-352, (1981)

[8]

Andersen A.R., Friberg L., Olsen T.S., Olesen J., Delayed hyperemia following hypoperfusion in classic migraine. Single photon emission computed tomographic demonstration, Arch Neurol, 45, pp. 154-159, (1988)

[9]

Andersson J.L.R., Muhr C., Lilja A., Et al., Regional cerebral blood flow and oxygen metabolism during migraine with and without aura, Cephalalgia, 17, pp. 570-579, (1997)

[10]

Netsiri C., Bradley D.P., Takeda T., Et al., A delayed class of BOLD waveforms associated with spreading depression in the feline cerebral cortex can be detected and characterised using independent component analysis (ICA), Magn Reson Imaging, 21, pp. 1097-1110, (2003)

← 1 2 3 4 5 →