Zinc homeostasis and signaling in health and diseases

被引：439

作者：

Fukada, Toshiyuki ^{[2
]}

Yamasaki, Satoru ^{[2
]}

Nishida, Keigo ^{[2
,3
]}

Murakami, Masaaki ^{[1
]}

Hirano, Toshio ^{[1
,2
]}

机构：

[1] Osaka Univ, WPI Immunol Frontier Res Ctr, Grad Sch Med,Labs Dev Immunol, JST CREST,Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan

[2] RIKEN, Res Ctr Allergy & Immunol, Lab Cytokine Signaling, Kanagawa 2300045, Japan

[3] Osaka Univ, Grad Sch Frontier Biosci, Cooperat Program, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2011年 / 16卷 / 07期

关键词：

Zinc; Signaling; Zinc transporter; Metallothionein; Disease; LONG-TERM POTENTIATION; PROTEIN-KINASE-C; SYNAPTICALLY RELEASED ZINC; SODIUM-INDUCED COLITIS; BREAST-CANCER CELLS; LABILE ZINC; METALLOTHIONEIN-I; ACRODERMATITIS-ENTEROPATHICA; AIRWAY INFLAMMATION; MEDIATED INHIBITION;

D O I：

10.1007/s00775-011-0797-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory dysfunctions. Zn homeostasis is regulated through Zn transporters, permeable channels, and metallothioneins. Recent studies highlight Zn's dynamic activity and its role as a signaling mediator. Zn acts as an intracellular signaling molecule, capable of communicating between cells, converting extracellular stimuli to intracellular signals, and controlling intracellular events. We have proposed that intracellular Zn signaling falls into two classes, early and late Zn signaling. This review addresses recent findings regarding Zn signaling and its role in physiological processes and pathogenesis.

引用

页码：1123 / 1134

页数：12

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