Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

被引：84

作者：

Yamagishi, S

Takeuchi, M

Matsui, T

Nakamura, K

Imaizumi, T

Inoue, H

机构：

[1] Kurume Univ, Sch Med, Dept Internal Med 3, Kurume, Fukuoka 8300011, Japan

[2] Hokuriku Univ, Fac Pharmaceut Sci, Dept Pathophysiol Sci, Kanazawa, Ishikawa 9201181, Japan

[3] Kurume Univ, Sch Med, Radioisotope Inst Basic & Clin Med, Kurume, Fukuoka 8300011, Japan

来源：

FEBS LETTERS | 2005年 / 579卷 / 20期

关键词：

advanced glycation end products; angiotensin II; diabetic retinopathy; oxidative stress; pericyte loss; receptor for AGEs;

D O I：

10.1016/j.febslet.2005.06.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-kappa B activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4265 / 4270

页数：6

共 41 条

[1]

Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes [J].