Kinetic studies to investigate lipoprotein metabolism

被引：25

作者：

Boren, J. ^{[1
]}

Taskinen, M. -R. ^{[2
]}

Adiels, M. ^{[3
]}

机构：

[1] Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, SE-41345 Gothenburg, Sweden

[2] Univ Helsinki, Dept Med, Helsinki, Finland

[3] Univ Gothenburg, Dept Math Sci, SE-41345 Gothenburg, Sweden

来源：

JOURNAL OF INTERNAL MEDICINE | 2012年 / 271卷 / 02期

关键词：

kinetics; lipoproteins; metabolism; stable isotopes; very low-density lipoproteins; NONALCOHOLIC FATTY LIVER; APOLIPOPROTEIN-B METABOLISM; MULTICOMPARTMENTAL MODEL; TRIGLYCERIDE-METABOLISM; INSULIN-RESISTANCE; SAAM II; VLDL; ISOTOPE; DISEASE; OVERPRODUCTION;

D O I：

10.1111/j.1365-2796.2011.02497.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To develop novel strategies for the prevention and treatment of dyslipidaemia, it is essential to understand the pathophysiology of dyslipoproteinaemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labelled with stable isotopes and mathematical modelling provides a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering understanding of the pathogenesis of dyslipoproteinaemia.

引用

页码：166 / 173

页数：8

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