Immediate post-shock chest compressions improve outcome from prolonged ventricular fibrillation

被引：31

作者：

Berg, Robert A. ^{[1
,2
]}

Hilwig, Ronald W. ^{[1
]}

Berg, Marc D. ^{[1
,2
]}

Berg, David D. ^{[1
]}

Samson, Ricardo A. ^{[1
,2
]}

Indik, Julia H. ^{[1
]}

Kern, Karl B. ^{[1
]}

机构：

[1] Univ Arizona, Coll Med, Sarver Heart Ctr, Tucson, AZ 85724 USA

[2] Univ Arizona, Steele Childrens Res Ctr, Tucson, AZ 85724 USA

来源：

RESUSCITATION | 2008年 / 78卷 / 01期

基金：

美国国家卫生研究院;

关键词：

chest compressions; cardiac arrests; ventricular fibrillation; defibrillation; cardiopulmonary resuscitation; heart arrest; automated external defibrillator (AED); outcome;

D O I：

10.1016/j.resuscitation.2008.02.014

中图分类号：

R4 [临床医学];

学科分类号：

1002 [临床医学]; 100602 [中西医结合临床];

摘要：

Aim: This study was designed to test the hypothesis that immediate post-shock chest compressions improve outcome from prolonged ventricular fibrillation (VF) compared with typical "hands off" period (i.e., delayed post-shock compressions) associated with AED use. Materials and methods: After 7.5 min of untreated VF, 36 domestic swine (26 1 kg) were treated with 200 J biphasic shocks and randomly assigned to: (1) 1 min of immediate post-shock chest compressions or (2) simulated pre-hospital automated external defibrillator (AED) care with delays in post-shock chest compressions. Return of spontaneous circulation (ROSC) occurred in 7/18 immediate chest compressions animals within 2 min of the first shock versus 0/18 AED animals (P < 0.01). Ten of 18 immediate chest compressions animals attained ROSC compared with 3/18 AED animals (P < 0.05). Nine of 18 immediate chest compressions swine were alive at 24 and 48 h compared with 3/18 AED swine (P < 0.05). All 48-h survivors had good neurologic outcomes. Among the 21 animals that defibrillated with the first shock, ROSC was attained in 7/10 immediate chest compressions animals within 2 min of the first shock compared with 0/11 AED animals (P = 0.001), and 48-h survival was attained in 8/10 versus 3/11, respectively (P < 0.05). Conclusions: Immediate post-shock chest compressions can substantially improve outcome from prolonged VF compared with simulated pre-hospital AED care. (c) 2008 Elsevier Ireland Ltd. All. rights reserved.

引用

页码：71 / 76

页数：6

共 34 条

[1]

Chest compression rates during cardiopulmonary resuscitation are suboptimal - A prospective study during in-hospital cardiac arrest [J].