Clinical relevance and biology of circulating tumor cells

被引：122

作者：

Bednarz-Knoll, Natalia ^{[1
]}

Alix-Panabieres, Catherine ^{[2
,3
,4
]}

Pantel, Klaus ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Tumor Biol, D-20246 Hamburg, Germany

[2] St Eloi Hosp, Univ Med Ctr, Inst Res Biotherapy, Lab Rare Human Circulating Cells, F-34295 Montpellier 5, France

[3] Arnaud Villeneuve Hosp, Univ Med Ctr, Lab Cell & Hormonal Biol, F-34295 Montpellier 5, France

[4] Univ Inst Clin Res, UM1, EA2415 Epidemiol Biostat & Publ Hlth, F-34093 Montpellier 5, France

来源：

BREAST CANCER RESEARCH | 2011年 / 13卷 / 06期

关键词：

METASTATIC BREAST-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; BONE-MARROW; PERIPHERAL-BLOOD; MOLECULAR CHARACTERIZATION; HER2; STATUS; STEM-CELL; PROGNOSTIC VALUE; RARE CELLS; RT-PCR;

D O I：

10.1186/bcr2940

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Most breast cancer patients die due to metastases, and the early onset of this multistep process is usually missed by current tumor staging modalities. Therefore, ultrasensitive techniques have been developed to enable the enrichment, detection, isolation and characterization of disseminated tumor cells in bone marrow and circulating tumor cells in the peripheral blood of cancer patients. There is increasing evidence that the presence of these cells is associated with an unfavorable prognosis related to metastatic progression in the bone and other organs. This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer.

引用

页数：11

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