Probe beam deflection study on electrochemically controlled release of 5-fluorouracil

被引：5

作者：

Huang, H ^{[1
]}

Liu, CW ^{[1
]}

Liu, BF ^{[1
]}

Cheng, GJ ^{[1
]}

Dong, SJ ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Electroanalyt Chem Lab, Changchun 130022, Jilin, Peoples R China

来源：

ELECTROCHIMICA ACTA | 1998年 / 43卷 / 09期

基金：

中国国家自然科学基金;

关键词：

5-fluorouracil; polypyrrole; electrochemically controlled release; probe beam deflection;

D O I：

10.1016/S0013-4686(97)00280-6

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

In this paper, the polypyrrole (PPy) film modified electrodes are used as an electroreleasing reservoir. The electrochemically controlled release of 5-fluorouracil (5-FU) from a PPy film modified electrode to aqueous electrolytes is studied by the in situ probe beam deflection (PBD) method combined with cyclic voltammetry (CV) and chronoamperometry (CA). The PBD results reveal that the release of 5-FU from PPy film depends on the electrochemical redox process of the PPy film electrode. The released amount is controlled by the reduction potential and is proportional to the thickness of the film. The exchange of 5-FU anions with Cl- on an open circuit is slow on the time scale of minutes, but the release of 5-FU anions can proceed quickly at -0.6 V (vs Ag/AgCl). The amount of released 5-FU decreases with the time that the PPy film is soaked in aqueous solution. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：999 / 1004

页数：6

共 30 条

[1] ELECTROCHEMICAL MASS-TRANSPORT STUDIED BY PROBE BEAM DEFLECTION - POTENTIAL STEP EXPERIMENTS [J].