Columnar packing of telomeric nucleosomes

被引：54

作者：

Fajkus, J

Trifonov, EN

机构：

[1] Acad Sci Czech Republic, Inst Biophys, CZ-61265 Brno, Czech Republic

[2] Masaryk Univ, Dept Funct Gen & Prote, CZ-61265 Brno, Czech Republic

[3] Weizmann Inst Sci, Dept Biol Struct, IL-76100 Rehovot, Israel

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 280卷 / 04期

关键词：

telomere; columnar nucleosome packing; telomeric chromatin;

D O I：

10.1006/bbrc.2000.4208

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres belong to the key functional elements of eukaryotic chromosomes. Like all the other parts of the genome, they exist and function as complexes of DNA with histones and various nonhistone proteins, including specific telomere-binding proteins. Studies of telomeric chromatin have shown on the one hand a lack of nucleosome positioning and on the other hand a specific nucleosome spacing as revealed by micrococcal nuclease digestion. Based on these properties and on accumulated experimental data, we present a model for a columnar packing of nucleosomes in telomeric chromatin. (C) 2001 Academic Press.

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收藏

页码：961 / 963

页数：3

相关论文

共 26 条

[1] Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin [J].

Bednar, J ;

Horowitz, RA ;

Grigoryev, SA ;

Carruthers, LM ;

Hansen, JC ;

Koster, AJ ;

Woodcock, CL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (24) :14173-14178

[2] Condensation of rat telomere-specific nucleosomal arrays containing unusually short DNA repeats and histone H1 [J].

Bedoyan, JK ;

Lejnine, S ;

Makarov, VL ;

Langmore, JP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (31) :18485-18493

[3] Two types of telomeric chromatin in Tetrahymena thermophila [J].

Cohen, P ;

Blackburn, EH .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 280 (03) :327-344

[4] Nucleosome dynamics. III. Histone tail-dependent fluctuation of nucleosomes between open and closed DNA conformations. Implications for chromatin dynamics and the linking number paradox. A relaxation study of mononucleosomes on DNA minicircles [J].

De Lucia, F ;

Alilat, M ;

Sivolob, A ;

Prunell, A .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (03) :1101-1119

[5] HYDRODYNAMIC STUDIES OF THE INTERACTION BETWEEN NUCLEOSOME CORE PARTICLES AND CORE HISTONES [J].

EISENBERG, H ;

FELSENFELD, G .

JOURNAL OF MOLECULAR BIOLOGY, 1981, 150 (04) :537-555

[6] ORGANIZATION OF TELOMERIC AND SUBTELOMERIC CHROMATIN IN THE HIGHER-PLANT NICOTIANA-TABACUM [J].

FAJKUS, J ;

KOVARIK, A ;

KRALOVICS, R ;

BEZDEK, M .

MOLECULAR & GENERAL GENETICS, 1995, 247 (05) :633-638

[7] Genomic organisation and chromatin structure of Plasmodium falciparum chromosome ends [J].

Figueiredo, LM ;

Pirritt, LA ;

Scherf, A .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 106 (01) :169-174

[8] Mammalian telomeres end in a large duplex loop [J].

Griffith, JD ;

Comeau, L ;

Rosenfield, S ;

Stansel, RM ;

Bianchi, A ;

Moss, H ;

de Lange, T .

CELL, 1999, 97 (04) :503-514

[9] Liquid crystalline ordering of nucleosome core particles under macromolecular crowding conditions: Evidence for a discotic columnar hexagonal phase [J].

Leforestier, A ;

Livolant, F .

BIOPHYSICAL JOURNAL, 1997, 73 (04) :1771-1776

[10] CONSERVED NUCLEOPROTEIN STRUCTURE AT THE ENDS OF VERTEBRATE AND INVERTEBRATE CHROMOSOMES [J].

LEJNINE, S ;

MAKAROV, VL ;

LANGMORE, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (06) :2393-2397