Enzymatic synthesis of cyclic triterpenes

被引：184

作者：

Abe, Ikuro ^{[1
]}

机构：

[1] Univ Shizuoka, Japan Sci & Technol Agcy, Sch Pharmaceut Sci, Shizuoka 4228526, Japan

来源：

NATURAL PRODUCT REPORTS | 2007年 / 24卷 / 06期

关键词：

D O I：

10.1039/b616857b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review covers recent advances in the chemistry and enzymology of squalene cyclase and oxidosqualene cyclase. The enzymatic cyclizations of squalene and oxidosqualene are the most remarkable steps in the biosynthesis of sterols and triterpenes. The polyenes are converted to variouspolycyclic triterpenes by different enzyme systems employing only small modification of the active-site. Recent crystallographic and structure-based mutagenesis studies as well as utilization of chemically synthesized active- site probes have begun to reveal intimate structural details of the enzyme-templated cyclization reactions. 126 References are cited.

引用

页码：1311 / 1331

页数：21

共 128 条

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Abe, I
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Abe, I
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Shibuya, M
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[4] Cyclization of (3S)29-methylidene-2,3-oxidosqualene by bacterial squalene:hopene cyclase: Irreversible enzyme inactivation and isolation of an unnatural dammarenoid
Abe, I
Dang, TY
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Abe, I
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