Leptin: A modulator of alcohol craving?

被引：104

作者：

Kiefer, F ^{[1
]}

Jahn, H ^{[1
]}

Jaschinski, M ^{[1
]}

Holzbach, R ^{[1
]}

Wolf, K ^{[1
]}

Naber, D ^{[1
]}

Wiedemann, K ^{[1
]}

机构：

[1] Univ Hamburg, Hosp Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany

来源：

BIOLOGICAL PSYCHIATRY | 2001年 / 49卷 / 09期

关键词：

leptin; cortisol; HPA; alcoholism; craving; withdrawal;

D O I：

10.1016/S0006-3223(01)01081-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Leptin has been shown to regulate food intake and energy expenditure. Because leptin acts via regulation of appetite, il e studied the hypothesis that suggests leptin modulates craving for alcohol as well. Methods: We, studied leptin plasma concentrations (RIA) both in alcoholic subjects during inpatient detoxification :(day 1: n = 78, day 14: n = 60) and in healthy control subjects (in = 30), To rule out interference with the activation of the HPA axis during alcohol withdrawal, we also evaluated cortisol plasma levels (RIA). Results: We found plasma leptin and cortisol elevated at onset of withdrawal decreasing significantly up to day 14. Leptin (and the body-mass corrected ratio leptin/BMI) was highly correlated with self-rated craving. No correlations of craving with cortisol and BMI were observed Conclusions: We suggest that leptin may modulate withdrawal-induced craving in alcoholic subjects. (C) 2001 Society of Biological Psychiatry.

引用

页码：782 / 787

页数：6

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