Androgen levels, insulin sensitivity, and early insulin response in women with polycystic ovary syndrome: a long-term follow-up study

被引：16

作者：

Hudecova, Miriam ^{[1
]}

Holte, Jan ^{[1
]}

Moby, Lena ^{[1
]}

Olovsson, Matts ^{[1
]}

Stridsberg, Mats ^{[2
]}

Larsson, Anders ^{[2
]}

Berglund, Lars ^{[3
]}

Berne, Christian ^{[2
]}

Poromaa, Inger Sundstrom ^{[1
]}

机构：

[1] Uppsala Univ, Dept Womens & Childrens Hlth, S-75185 Uppsala, Sweden

[2] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[3] Uppsala Clin Res Ctr, Uppsala, Sweden

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 03期

关键词：

Polycystic ovary syndrome; long-term follow-up; insulin sensitivity; intravenous glucose tolerance test; hyperinsulinemic; euglycemic clamp; testosterone; HORMONE-BINDING GLOBULIN; MENSTRUAL-CYCLE; RESISTANCE; SECRETION; GLUCOSE; HISTORY; INDEX; RISK;

D O I：

10.1016/j.fertnstert.2010.09.050

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Thirty-four women with polycystic ovary syndrome who previously had participated in studies with intravenous glucose tolerance test and hyperinsulinemic, euglycemic clamp between 1987 and 1995 underwent anthropometric, endocrine (T and sex-hormone binding globulin serum concentration), and metabolic (intravenous glucose tolerance test, hyperinsulinemic, euglycemic clamp, and androgens) measurements. Free androgen levels and beta-cell function decreased over time in women with polycystic ovary syndrome, but insulin sensitivity remained unaltered. (Fertil Steril (R) 2011;95:1146-8. (c) 2011 by American Society for Reproductive Medicine.)

引用

页码：1146 / 1148

页数：3

共 19 条

[1]

Impact of Menstrual Cycle Phase on Insulin Sensitivity Measures and Fasting Lipids [J].

Bingley, C. A. ;

Gitau, R. ;

Lovegrove, J. A. .

HORMONE AND METABOLIC RESEARCH, 2008, 40 (12) :901-906

[2]

The mean and the biological variation of insulin resistance does not differ between polycystic ovary syndrome and type 2 diabetes [J].

Cho, Li Wei ;

Jayagopal, V. ;

Kilpatrick, E. S. ;

Atkin, S. L. .

ANNALS OF CLINICAL BIOCHEMISTRY, 2009, 46 :218-221

[3]

Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome [J].

Cibula, D ;

Cífková, R ;

Fanta, M ;

Poledne, R ;

Zivny, J ;

Skibová, J .

HUMAN REPRODUCTION, 2000, 15 (04) :785-789

[4]

DAHLGREN E, 1992, FERTIL STERIL, V57, P505

[5]

Insulin sensitivity and sex steroid hormone levels during the menstrual cycle in healthy women with non-insulin-dependent diabetic parents [J].

González-Ortiz, M ;

Martínez-Abundis, E ;

Lifshitz, A .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1998, 46 (03) :187-190

[6]

DECREASED INSULIN-SECRETION AND INCREASED INSULIN-RESISTANCE ARE INDEPENDENTLY RELATED TO THE 7-YEAR RISK OF NIDDM IN MEXICAN-AMERICANS [J].

HAFFNER, SM ;

MIETTINEN, H ;

GASKILL, SP ;

STERN, MP .

DIABETES, 1995, 44 (12) :1386-1391

[7]

ENHANCED EARLY INSULIN-RESPONSE TO GLUCOSE IN RELATION TO INSULIN-RESISTANCE IN WOMEN WITH POLYCYSTIC-OVARY-SYNDROME AND NORMAL GLUCOSE-TOLERANCE [J].

HOLTE, J ;

BERGH, T ;

BERNE, C ;

BERGLUND, L ;

LITHELL, H .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (05) :1052-1058

[8]

Long-term follow-up of patients with polycystic ovary syndrome: reproductive outcome and ovarian reserve [J].

Hudecova, M. ;

Holte, J. ;

Olovsson, M. ;

Sundstrom Poromaa, I. .

HUMAN REPRODUCTION, 2009, 24 (05) :1176-1183

[9]

Growth hormone secretory dynamics over the menstrual cycle [J].

Jaffe, CA ;

Ocampo-Lim, B ;

Guo, WS ;

Krueger, K ;

Sugahara, I ;

Demott-Friberg, R ;

Barkan, AL .

ENDOCRINE JOURNAL, 2000, 47 (05) :549-556

[10]

JIA M C, 1992, Advances in Contraception, V8, P33, DOI 10.1007/BF01849346

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