Synthesis of 3,4-disubstituted 2,5-dihydrofurans starting from the Baylis-Hillman adducts via consecutive radical cyclization, halolactonization, and decarboxylation strategy

被引：42

作者：

Gowrisankar, S

Lee, KY

Kim, JN ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea

[2] Chonnam Natl Univ, Inst Basic Sci, Kwangju 500757, South Korea

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 29期

关键词：

2,5-dihydrofurans; radical cyclization; halolactonization; Baylis-Hillman adducts;

D O I：

10.1016/j.tetlet.2005.05.057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthetic method of 3,4-disubstituted 2,5-dihydrofurans and 2,5-dihydropyrroles starting from the Baylis-Hillman adducts was developed. The 2,5-dihydrofuran skeleton was constructed via the consecutive radical cyclization, hydrolysis, halolactonization, and spontaneous decarboxylation strategy starting from the modified Baylis-Hillmail adducts. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：4859 / 4863

页数：5

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