BDNF and trkB mRNAs oscillate in rat brain during the light-dark cycle

被引：93

作者：

Bova, R

Micheli, MR

Qualadrucci, P

Zucconi, GG

机构：

[1] Univ Perugia, Dept Cellular & Mol Biol, I-06123 Perugia, Italy

[2] Univ Rome 2, Dept Expt Med & Biochem Sci, I-00173 Rome, Italy

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 57卷 / 02期

关键词：

brain-derived neurotrophic factor; tyrosine kinase receptor; light-dark cycle; cerebral cortex; hippocampus; RT-PCR;

D O I：

10.1016/S0169-328X(98)00092-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study, we investigated whether in basal conditions the different functional states occurring during a 24-h cycle are reflected by the expression of brain-derived neurotrophic factor (BDNF) and its receptor, trkB, in rat cerebral cortex and hippocampus. Using semiquantitative RT-PCR assay, the levels of both BDNF and trkB mRNAs were found to undergo significant variation in a 24-h period. The strongest variation was detected in the hippocampus, where the ratio between maximum and minimum levels was about 3.5 and 17.5 for BDNF and trkB, respectively. These findings provide the first evidence that, in the absence of any experimental manipulation, the expression of a neurotrophin and its receptor undergoes diurnal oscillation, possibly related to the physiological variations of the activity level. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：321 / 324

页数：4

共 25 条

[1] BRAIN-DERIVED NEUROTROPHIC FACTOR INCREASES SURVIVAL AND DIFFERENTIATED FUNCTIONS OF RAT SEPTAL CHOLINERGIC NEURONS IN CULTURE [J].