Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing

被引：539

作者：

Yagi, Hiroshi ^{[1
,2
,3
]}

Soto-Gutierrez, Alejandro ^{[1
,2
]}

Parekkadan, Biju ^{[1
,2
]}

Kitagawa, Yuko ^{[3
]}

Tompkins, Ronald G. ^{[1
,2
]}

Kobayashi, Naoya ^{[4
]}

Yarmush, Martin L. ^{[1
,2
,5
]}

机构：

[1] Shriners Hosp Children, Massachusetts Gen Hosp, Ctr Engn Med & Surg Serv, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Keio Univ, Sch Med, Dept Surg, Tokyo 160, Japan

[4] Okayama Univ, Dept Surg, Grad Sch Med & Dent, Okayama, Japan

[5] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ USA

来源：

CELL TRANSPLANTATION | 2010年 / 19卷 / 6-7期

关键词：

Immunosuppression; T-cell proliferation; Stem cell migration; Interferon-gamma (IFN-gamma); Nuclear factor-kappa B (NF-kappa B); MARROW STROMAL CELLS; TOLL-LIKE RECEPTORS; BREAST-CANCER METASTASIS; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; BONE-MARROW; DENDRITIC CELLS; IN-VIVO; IFN-GAMMA; INDOLEAMINE 2,3-DIOXYGENASE;

D O I：

10.3727/096368910X508762

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissue. A growing corpus of studies have highlighted two important aspects of MSC therapy: 1) MSCs can modulate T-cell-mediated immunological responses, and (2) systemically administered MSCs home to sites of ischemia or injury. In this review, we describe the known mechanisms of immunomodulation and homing of MSCs. First, we examine the low immunogenicity of MSCs and their antigen presentation capabilities. Next, we discuss the paracrine interactions between MSCs and innate [dendritic cells (DC)] and adaptive immune cells (T lymphocytes) with a focus on prostaglandin E-2 (PGE(2)), indoleamine 2,3-dioxygenase (IDO), and toll-like receptor (TLR) signaling pathways. We transition to outline the steps of activation, rolling/adhesion, and transmigration of MSCs into target tissues during inflammatory or ischemic conditions. These aspects of MSC grafts immunomodulation and homing are contextualized to understand a reported side effect of MSC therapy, cancer development.

引用

页码：667 / 679

页数：13

共 109 条

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