Centromeric chromatin makes its mark

被引：19

作者：

Dunleavy, E ^{[1
]}

Pidoux, A ^{[1
]}

Allshire, R ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Biol Sci, Inst Cell Biol, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 04期

关键词：

D O I：

10.1016/j.tibs.2005.02.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-translational modifications of core histones, particularly in the N terminus, seem to define different chromatin states in the genome. For instance, actively transcribed regions of euchromatin have a completely different set of ' marks ' compared with silent heterochromatin. Recent analyses surprisingly demonstrate that, in addition to containing the histone H3 variant CENP-A, the centromeric chromatin that underlies the kinetochore bears a distinct combination of histone H3 modifications.

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页码：172 / 175

页数：4

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