Comparison of four serological tests 70 determine the CagA or VacA status of Helicobacter pylori strains

被引：37

作者：

Yamaoka, Y

Kodama, T

Graham, DY

Kashima, K

机构：

[1] Vet Affairs Med Ctr, Dept Med, Houston, TX 77030 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Kyoto Prefectural Univ Med, Dept Internal Med 3, Kamikyo Ku, Kyoto 602, Japan

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1998年 / 36卷 / 11期

关键词：

D O I：

10.1128/JCM.36.11.3433-3434.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We compared four tests for antibodies to CagA or VacA, HelicoBlot 2.0, RIDA Blot Helicobacter, CHIRON RIBA H. pylori SIA, and an enzyme-linked immunosorbent assay using recombinant CagA. Immunoblot assays were accurate for determining Helicobacter pylori status but poor for determining CagA or VacA status (accuracy, 66 to 80% for CagA status and 34 to 67% for VacA status). None can be recommended for determining CagA or VacA status.

引用

收藏

页码：3433 / 3434

页数：2

相关论文

共 20 条

[1]

BLASER MJ, 1995, CANCER RES, V55, P2111

[2]

Ching CK, 1996, AM J GASTROENTEROL, V91, P949

[3] SEROLOGIC DETECTION OF INFECTION WITH CAGA(+) HELICOBACTER-PYLORI STRAINS [J].

COVER, TL ;

GLUPCZYNSKI, Y ;

LAGE, AP ;

BURETTE, A ;

TUMMURU, MKR ;

PEREZPEREZ, GI ;

BLASER, MJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (06) :1496-1500

[4] CHARACTERIZATION OF AND HUMAN SEROLOGIC RESPONSE TO PROTEINS IN HELICOBACTER-PYLORI BROTH CULTURE SUPERNATANTS WITH VACUOLIZING CYTOTOXIN ACTIVITY [J].

COVER, TL ;

DOOLEY, CP ;

BLASER, MJ .

INFECTION AND IMMUNITY, 1990, 58 (03) :603-610

[5] Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: Lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis [J].

Graham, DY ;

Genta, RM ;

Graham, DP ;

Crabtree, JE .

JOURNAL OF CLINICAL PATHOLOGY, 1996, 49 (10) :829-832

[6]

Heikkinen M, 1997, AM J GASTROENTEROL, V92, P2225

[7]

HookNikanne J, 1997, CLIN DIAGN LAB IMMUN, V4, P592

[8] Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan [J].

Ito, Y ;

Azuma, T ;

Ito, S ;

Miyaji, H ;

Hirai, M ;

Yamazaki, Y ;

Sato, F ;

Kato, T ;

Kohli, Y ;

Kuriyama, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 1997, 35 (07) :1710-1714

[9] HELICOBACTER-PYLORI AND ATROPHIC GASTRITIS - IMPORTANCE OF THE CAGA STATUS [J].

KUIPERS, EJ ;

PEREZPEREZ, GI ;

MEUWISSEN, SGM ;

BLASER, MJ .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (23) :1777-1780

[10] High seropositivity of anti-CagA antibody in Helicobacter pylori-infected patients irrelevant to peptic ulcers and normal mucosa in Japan [J].

Maeda, S ;

Kanai, F ;

Ogura, K ;

Yoshida, H ;

Ikenoue, T ;

Takahashi, M ;

Kawabe, T ;

Shiratori, Y ;

Omata, M .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (09) :1841-1847