Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease

被引：152

作者：

Shen, Gong-Qing ^{[1
,2
,3
,4
]}

Li, Lin ^{[1
,2
,3
,4
]}

Rao, Shaoqi ^{[1
,2
,3
,4
]}

Abdullah, Kalil G. ^{[1
,2
,3
,4
]}

Ban, Ji Min ^{[5
]}

Lee, Bok-Soo ^{[5
]}

Park, Jeong Euy ^{[5
]}

Wang, Qing K. ^{[1
,2
,3
,4
,6
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Dept Mol Cardiol, Cleveland, OH 44106 USA

[2] Cleveland Clin, Ctr Cardiovasc Genet, Cleveland, OH 44106 USA

[3] Cleveland Clin, Dept Cardiovasc Med, Cleveland, OH 44106 USA

[4] Cleveland Clin, Case Western Reserve Univ, Cleveland Clin Lerner Coll Med, Dept Mol Med, Cleveland, OH 44106 USA

[5] Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea

[6] Huo Zhong Univ Sci, Minist Educ, Key Lab Mol Biophys, Wuhan, Peoples R China

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2008年 / 28卷 / 02期

关键词：

coronary artery disease; myocardial infarction; single nucleotide polymorphism; association study; Asian population;

D O I：

10.1161/ATVBAHA.107.157248

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-Recent genome-wide association studies have identified 4 SNPs on chromosome 9p21 associated with CAD (rs10757274 and rs2383206) and myocardial infarction (MI: rs2383207 and rs10757278) in White populations in Northern Europe and North America. We aimed to determine whether this locus confers significant susceptibility to CAD in a South Korean population, and thus cross-race susceptibility to CAD. Methods and Results-We performed a case-control association study with 611 unrelated CAD patients and 294 normal controls from South Korea. Allelic associations of SNPs and SNP haplotypes with CAD were evaluated. Multivariate logistic regression analysis was used to adjust effects of clinical covariates. We found that 4 SNPs on chromosome 9p21 were associated with susceptibility to CAD in a South Korean population. The association remained significant after adjusting for significant clinical covariates (P = 0.001 to 0.024). We identified one risk haplotype (GGGG; P = 0.017) and one protective haplotype (AAAA; P = 0.007) for development of CAD. Further analysis suggested that the SNPs probably confer susceptibility to CAD in a dominance model (covariates-adjusted P = 0.001 to 0.024; OR = 2.37 to 1.54). This represents the first study that expands association of these 9p21 SNPs with CAD beyond White populations. Conclusion-Chromosome 9p21 is an important susceptibility locus that confers high cross-race risk for development of CAD.

引用

页码：360 / 365

页数：6

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