Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and their selective elaboration

被引：5

作者：

Eckhardt, Matthias ^{[1
]}

Hauel, Norbert ^{[1
]}

Langkopf, Elke ^{[1
]}

Himmelsbach, Frank ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharma GmbH & Co KG, Dept Chem Res, D-88400 Biberach, Germany

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 12期

关键词：

imidazoles; imidazopyridazinones; regiocontrol; combinatorial chemistry;

D O I：

10.1016/j.tetlet.2008.01.102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two synthetic routes to the versatile 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accomplished. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1931 / 1934

页数：4

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