Structural basis of molecular mimicry

被引：82

作者：

Wucherpfennig, KW ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

来源：

JOURNAL OF AUTOIMMUNITY | 2001年 / 16卷 / 03期

关键词：

D O I：

10.1006/jaut.2000.0499

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infectious agents are thought to play an important role in the development of autoimmune diseases. Sequence similarity between infectious agents and self-proteins (molecular mimicry) has been proposed as a mechanism for the induction of autoimmunity [1]. However, it has been difficult to identify microbial peptides that activate autoreactive T cells using conventional sequence alignments. This chapter reviews progress made in the identification of such microbial peptides based on the analysis of structural features that are important for TCR recognition of MHC-bound peptides [2]. (C) 2001 Academic Press.

引用

页码：293 / 302

页数：10

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