Clearing the way to mechanisms of autoimmunity

被引：72

作者：

Rosen, A

Casciola-Rosen, L

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 06期

关键词：

D O I：

10.1038/89034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice with mutations in the Mer tyrosine kinase have deficits in the clearance of apoptotic thymocytes and increased titers of anti-DNA autoantibodies. These findings provide new in vivo evidence to suggest that impairments in clearance of apoptotic cells may underlie systemic autoimmunity.

引用

页码：664 / 665

页数：2

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