The UNC-104/KIF1 family of kinesins

被引：28

作者：

Bloom, GS ^{[1
]}

机构：

[1] Univ Virginia, Dept Biol, Charlottesville, VA 22903 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(00)00171-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most UNC-104/KIF1 kinesins are monomeric motors that transport membrane-bounded organelles toward the plus ends of microtubules. Recent evidence implies that KIF1A, a synaptic vesicle motor, moves processively. This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.

引用

页码：36 / 40

页数：5

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