Adacolumn leucocytapheresis for ulcerative colitis: clinical and endoscopic features of responders and unresponders

被引：14

作者：

Sacco, Rodolfo ^{[1
]}

Tanaka, Tomotaka ^{[2
]}

Yamamoto, Takayuki ^{[3
]}

Bresci, Giampaolo ^{[1
]}

Saniabadi, Abbi R. ^{[4
]}

机构：

[1] Pisa Univ Hosp, Dept Gastroenterol, Pisa, Italy

[2] Akitsu Prefectural Hosp, Dept Gastroenterol, Akitsu, Hiroshima, Japan

[3] Yokkaichi Social Insurance Hosp, Ctr Inflammatory Bowel Dis, Yokaichi, Mie, Japan

[4] Hamamatsu Univ Sch Med, Dept Pharmacol, Hamamatsu, Shizuoka 4313192, Japan

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2015年 / 9卷 / 03期

关键词：

colonoscopy; granulocyte and monocyte apheresis; loss of mucosal tissue; mucosal biopsy; neutrophils and monocytes; neutrophil infiltration; ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; PROINFLAMMATORY CD14(+)CD16(+)DR(++) MONOCYTES; CARRIER-BASED GRANULOCYTE; TUMOR-NECROSIS-FACTOR; SELECTIVE GRANULOCYTE; ADSORPTIVE APHERESIS; MEDICAL THERAPY; TGF-BETA; T-CELLS; APOPTOSIS;

D O I：

10.1586/17474124.2014.953060

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Cytokines such as TNF- have a validated role in the immunopathogensis of ulcerative colitis (UC), and intercepting inflammatory cytokines is currently the best option for maximizing treatment efficacy. One of the major sources of inflammatory cytokines are myeloid linage leucocytes (granulocytes, monocytes), which are present in great numbers in the colonic tissue. Their selective depletion by adsorptive granulocyte, monocyte apheresis (GMA), should be therapeutic in patients with UC, although until now efficacy outcomes have been both encouraging and disappointing. The authors' view is that in patients with UC, there is an evolving scope for therapeutic opportunity based on taking away the sources of inflammatory cytokines, also considering the favorable safety profile of GMA.

引用

页码：327 / 333

页数：7

共 53 条

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