The analysis of Neisseria meningitidis proteomes:: Reference maps and their applications

被引：12

作者：

Bernardini, Giulia ^{[1
]}

Braconi, Daniela ^{[1
]}

Santucci, Annalisa ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Biol Mol, I-53100 Siena, Italy

来源：

PROTEOMICS | 2007年 / 7卷 / 16期

关键词：

microevolution; Neisseria meningitidis; reference map; two-dimensional gel electrophoresis;

D O I：

10.1002/pmic.200700094

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Neisseria meningitidis is an encapsulated Gram-negative bacterium responsible for significant morbidity and mortality worldwide. The availability of meningococcal genome sequences in combination with the rapid growth of proteomic techniques and other high-throughput methods, provided new approaches to the analysis of bacterial system biology. This review considers the meningococcal reference maps so far published as a starting point aimed to elucidate bacterial physiology and pathogenicity, paying particular attention to proteins with potential vaccine and diagnostic applications.

引用

页码：2933 / 2946

页数：14

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