Total synthesis of (+)-okaramine J featuring an exceptionally facile N-reverse-prenyl to C-prenyl Aza-Claisen rearrangement

被引：59

作者：

Roe, JM

Webster, RAB

Ganesan, A ^{[1
]}

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Pfizer Global Res & Dev, Vet Med, Sandwich CT13 9NJ, Kent, England

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 16期

关键词：

D O I：

10.1021/ol034822n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Graphics The convergent total synthesis of (+)-okaramine J was achieved in a longest linear sequence of 12 steps from L-tryptophan tert-butyl ester. A key reaction was the acid-catalyzed room-temperature aza-Claisen rearrangement of a N-reverse-prenylated hexahydro[2,3-b]pyrroloindole to a C-prenylated derivative.

引用

页码：2825 / 2827

页数：3

共 40 条

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