Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase

被引：81

作者：

Liu, JH ^{[1
]}

Zschocke, S ^{[1
]}

Reininger, E ^{[1
]}

Bauer, R ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Pharmazeut Biol, D-40225 Dusseldorf, Germany

来源：

PLANTA MEDICA | 1998年 / 64卷 / 06期

关键词：

Angelica pubescens f. biserrata; Umbelliferae; 5-lipoxygenase; cyclooxygenase; linoleic acid; osthol; osthenol; falcarindiol; 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate;

D O I：

10.1055/s-2006-957507

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Linoleic acid, osthol, osthenol and two polyacetylenes, falcarindiol and 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1 -yl acetate were found to be the most active compounds responsible for the inhibitory activity of the dichloromethane extract of the roots of Angelica pubescens f. biserrata on 5-lipoxygenase (5-LO) and cyclooxygenase (COX-1) in vitro. They showed prominent inhibitory effect on 5-LO with IC50 values of 27.9 mu M, 36.2 mu M, 43.1 mu M, 9.4 mu M and 24.0 mu M, respectively. Linoleic acid, osthenol, falcarindiol and 11(S), 16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate exhibited inhibitory activity on COX-1 with IC50 values of 13.3 mu M, 64.3 mu M, 66.0 mu M and 73.3 mu M.

引用

页码：525 / 529

页数：5