Ordered mesoporous silica coated capillary for in-tube solid phase microextraction coupled to high performance liquid chromatography

Ordered mesoporous silica coating modified with octadecyl groups was introduced into the capillary for in-tube solid phase microextraction coupled to high performance liquid chromatography (in-tube SPME-HPLC). Improved extraction efficiency was demonstrated for the capillary when comparing with those of non-mesoporous structural coatings. The coatings produced by using different structure directing agents were compared and the highest sample capacity was achieved with the most ordered mesostructural coating. The capillary with the octadecyl modified ordered mesoporous silica coating was used to perform in-tube SPME-HPLC analysis of bisphenol A in water samples. Tap water and Donghu lake (Wuhan, China) water samples spiked with bisphenol A were tested under optimized conditions with the linearity ranged from 0.01 to 1 mu g/mL and the detection limits were found to be 2.8 and 2.9 ng/mL, respectively. The precision of the method was satisfactory with the R.S.D. values smaller than 2.7%. (c) 2005 Elsevier B.V. All rights reserved.