Efficient solid phase synthesis of 3,5-disubstituted hydantoins

被引：32

作者：

Nefzi, A ^{[1
]}

Ostresh, JM ^{[1
]}

Giulianotti, M ^{[1
]}

Houghten, RA ^{[1
]}

机构：

[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(98)01874-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient solid phase synthesis of 3,5-disubstituted hydantoins is described The treatment of a resin-bound diamino-acid containing dipeptide with carbonyldiimidazole or triphosgene afforded the five member ring hydantoins. A second site of diversity is included following N-acylation of the free amine side chain with a wide range of commercially available carboxylic acids. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8199 / 8202

页数：4

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