Efficient solid phase synthesis of 3,5-disubstituted hydantoins

被引:32
作者
Nefzi, A [1 ]
Ostresh, JM [1 ]
Giulianotti, M [1 ]
Houghten, RA [1 ]
机构
[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA
关键词
D O I
10.1016/S0040-4039(98)01874-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An efficient solid phase synthesis of 3,5-disubstituted hydantoins is described The treatment of a resin-bound diamino-acid containing dipeptide with carbonyldiimidazole or triphosgene afforded the five member ring hydantoins. A second site of diversity is included following N-acylation of the free amine side chain with a wide range of commercially available carboxylic acids. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:8199 / 8202
页数:4
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