Rule of six:: How does the Sendai virus RNA polymerase keep count?

被引:53
作者
Vulliémoz, D [1 ]
Roux, L [1 ]
机构
[1] Univ Geneva, Sch Med, Dept Genet & Microbiol, CH-1211 Geneva 4, Switzerland
关键词
D O I
10.1128/JVI.75.10.4506-4518.2001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The "rule of six" stipulates that the Paramyxovirus RNA polymerase efficiently replicates only viral genomes counting 6n + 0 nucleotides. Because the nucleocapsid proteins (N) interact with 6 nucleotides, an exact nucleotide-N match at the RNA 3'-OH end (3'-OH congruence) may be required for recognition of an active replication promoter. Alternatively, assuming that the six positions for the interaction of N with the nucleotides are not equivalent, the nucleotide position relative to N may be critical (N phase context). The replication abilities of various minireplicons, designed so that the 3'-OH congruence could be discriminated from the N phase context, were studied. The results strongly suggest that the application of the rule of six depends on the recognition of nucleotides positioned in the proper N phase context.
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页码:4506 / 4518
页数:13
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