Adrenal, kidney, and heart angiotensins in female murine Ren-2 transfected hypertensive rats

被引：28

作者：

Senanayake, PD

Smeby, RR

Martins, AS

Moriguchi, A

Kumagai, H

Ganten, D

Brosnihan, KB

机构：

[1] Cleveland Clin Fdn, Eye & Res Inst, Cleveland, OH 44195 USA

[2] Wake Forest Univ, Sch Med, Hypertens Ctr, Winston Salem, NC 27157 USA

来源：

PEPTIDES | 1998年 / 19卷 / 10期

关键词：

blood pressure; transgenic hypertension; angiotensin peptides; renin gene;

D O I：

10.1016/S0196-9781(98)00123-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We analyzed by high-performance liquid chromatography and radioimmunoassay angiotensin I (Ang I), Ang II, Ang-(1-7), and metabolites in the adrenal, kidney and heart of normotensive female Sprague-Dawley (SD) and transgenic hypertensive [TGR(mRen-2)27] rats carrying the murine Ren-2(d) renin gene. The monogenetic model of hypertensive rats had significant increases in adrenal Ang II; whereas in the kidney Ang II was unchanged, but Ang I and Ang-(1-7) were significantly lower. Cardiac Ang I, Ang II, and Ang-(2-10) were significantly reduced in transgenic rats, while Ang-(2-7) was increased. In SD and transgenic rats kidney and adrenal angiotensins increased primarily during estrus or proestrus. In female transgenic rats the increased adrenal Ang II and the sustained renal Ang II may contribute to the established phase of hypertension. (C) 1998 Elsevier Science Inc.

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收藏

页码：1685 / 1694

页数：10

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