Importance of neurological assessment before bone marrow transplantation for osteopetrosis

被引：24

作者：

Abinun, M ^{[1
]}

Newson, T ^{[1
]}

Rowe, PW ^{[1
]}

Flood, TJ ^{[1
]}

Cant, AJ ^{[1
]}

机构：

[1] Newcastle Gen Hosp, Childens Bone Marrow Transplantat Unit, Dept Pediat, Newcastle Upon Tyne Hosp NHS Trust, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1999年 / 80卷 / 03期

关键词：

osteopetrosis; retinal degeneration; generalised neurodegeneration; bone marrow transplantation;

D O I：

10.1136/adc.80.3.273

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Neurological complications of malignant infantile osteopetrosis are well recognised; successful bone marrow transplantation, when performed early in life, can prevent or halt some of them. In a subgroup of infants osteopetrosis is associated with primary retinal degeneration and/or generalised neurodegeneration. Bone marrow transplantation, in spite of being successful in correcting the osseous and haematological abnormalities, does not influence the progressive course of the neurodegenerative disorder. Thus, the recognition of this subgroup of infants with a very poor prognosis is essential before deciding on bone marrow transplantation.

引用

页码：273 / 274

页数：2

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