Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators

被引：21

作者：

Choi, Eun Mi ^{[1
]}

机构：

[1] Kyung Hee Univ, Grad Sch Educ, Dept Food & Nutr, Seoul 130701, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Honokiol; MC3T3-E1; cells; Differentiation; Bone resorbing cytokine; MESENCHYMAL STEM-CELLS; FACTOR-KAPPA-B; OXIDATIVE STRESS; RECEPTOR ACTIVATOR; RAT HEPATOCYTES; RANK LIGAND; DIFFERENTIATION; GROWTH; OSTEOPROTEGERIN; MITOCHONDRIA;

D O I：

10.1016/j.intimp.2011.05.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

There has been a strong interest in searching for natural therapies for osteoporosis. Honokiol is a phenolic compound isolated from the bark of Magnolia officinalis, a plant widely used in traditional medicine. In the present study, the effects of honokiol on the function of osteoblastic MC3T3-E1 cells were studied. Honokiol caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis, mineralization, glutathione content, and osteoprotegerin release in the cells (P<0.05). Moreover, honokiol significantly (P<0.05) decreased the production of osteoclast differentiation inducing factors such as TNF-alpha, IL-6, and receptor activator of nuclear factor-kB ligand (RANKL) in the presence of antimycin A. which inhibits mitochondrial electron transport and has been used as a ROS generator. These results demonstrate that honokiol may have positive effects on skeletal structure. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1541 / 1545

页数：5

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