Interaction of Helicobacter pylori with host cells:: function of secreted and translocated molecules

被引：80

作者：

Rieder, G ^{[1
]}

Fischer, W ^{[1
]}

Haas, R ^{[1
]}

机构：

[1] Univ Munich, Max Von Pettenkofer Inst, D-80336 Munich, Germany

来源：

CURRENT OPINION IN MICROBIOLOGY | 2005年 / 8卷 / 01期

关键词：

D O I：

10.1016/j.mib.2004.12.004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Secreted proteins are of general interest from the perspective of bacteria-host interaction. The gastric bacterial pathogen Helicobacter pylori uses a set of secreted and translocated proteins - including outer membrane adhesins, secreted extracellular enzymes and translocated effector proteins - to adapt to its extraordinary habitat, the gastric mucosa. Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system and its translocated effector protein, cytotoxin-associated antigen A (CagA). VacA targets not only epithelial cells, but also cells of the immune system and induces immunosuppression. CagA has been shown to interact with a growing set of eucaryotic signaling molecules in phosphorylation-dependent and -independent ways.

引用

页码：67 / 73

页数：7

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