Observation of a power-law memory kernel for fluctuations within a single protein molecule

被引：357

作者：

Min, W

Luo, GB

Cherayil, BJ

Kou, SC

Xie, XS ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Stat, Cambridge, MA 02138 USA

[3] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

PHYSICAL REVIEW LETTERS | 2005年 / 94卷 / 19期

关键词：

D O I：

10.1103/PhysRevLett.94.198302

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photoinduced electron transfer and found to be a stationary, time-reversible, and non-Markovian Gaussian process. Within the generalized Langevin equation formalism, we experimentally determine the memory kernel K(t), which is proportional to the autocorrelation function of the random fluctuating force. K(t) is a power-law decay, t(-0.51 +/- 0.07) in a broad range of time scales (10(-3)-10 s). Such a long-time memory effect could have implications for protein functions.

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页数：4

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共 26 条

[1] DYNAMICS OF LIGAND-BINDING TO MYOGLOBIN [J].

AUSTIN, RH ;

BEESON, KW ;

EISENSTEIN, L ;

FRAUENFELDER, H ;

GUNSALUS, IC .

BIOCHEMISTRY, 1975, 14 (24) :5355-5373

[2] ON CALCULATION OF AUTOCORRELATION FUNCTIONS OF DYNAMICAL VARIABLES [J].

BERNE, BJ ;

BOON, JP ;

RICE, SA .

JOURNAL OF CHEMICAL PHYSICS, 1966, 45 (04) :1086-&

[3] Stretched exponential decay and correlations in the catalytic activity of fluctuating single lipase molecules [J].

Flomenbom, O ;

Velonia, K ;

Loos, D ;

Masuo, S ;

Cotlet, M ;

Engelborghs, Y ;

Hofkens, J ;

Rowan, AE ;

Nolte, RJM ;

Van der Auweraer, M ;

de Schryver, FC ;

Klafter, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (07) :2368-2372

[4] THE ENERGY LANDSCAPES AND MOTIONS OF PROTEINS [J].

FRAUENFELDER, H ;

SLIGAR, SG ;

WOLYNES, PG .

SCIENCE, 1991, 254 (5038) :1598-1603

[5] Ultrafast electron transfer in the complex between fluorescein and a cognate engineered lipocalin protein, a so-called anticalin [J].

Götz, M ;

Hess, S ;

Beste, G ;

Skerra, A ;

Michel-Beyerle, ME .

BIOCHEMISTRY, 2002, 41 (12) :4156-4164

[6] Anomalous motion of membranes under a localized external potential [J].

Granek, R ;

Klafter, J .

EUROPHYSICS LETTERS, 2001, 56 (01) :15-21

[7] COMPLEX NONEXPONENTIAL RELAXATION IN MYOGLOBIN AFTER PHOTODISSOCIATION OF MBCO - MEASUREMENT AND ANALYSIS FROM 2-PS TO 56-MU-S [J].

JACKSON, TA ;

LIM, M ;

ANFINRUD, PA .

CHEMICAL PHYSICS, 1994, 180 (2-3) :131-140

[8] Aspects of protein reaction dynamics: Deviations from simple behavior [J].

Karplus, M .

JOURNAL OF PHYSICAL CHEMISTRY B, 2000, 104 (01) :11-27

[9] HOW MANY PHOTONS ARE NECESSARY FOR FLUORESCENCE-LIFETIME MEASUREMENTS [J].

KOLLNER, M ;

WOLFRUM, J .

CHEMICAL PHYSICS LETTERS, 1992, 200 (1-2) :199-204

[10] Generalized langevin equation with fractional Gaussian noise: Subdiffusion within a single protein molecule [J].

Kou, SC ;

Xie, XS .

PHYSICAL REVIEW LETTERS, 2004, 93 (18) :180603-1