FGF-2 Stimulates Periodontal Regeneration: Results of a Multi-center Randomized Clinical Trial

被引：207

作者：

Kitamura, M. ^{[2
]}

Akamatsu, M.

Machigashira, M. ^{[3
]}

Hara, Y. ^{[4
]}

Sakagami, R. ^{[5
]}

Hirofuji, T. ^{[6
]}

Hamachi, T.

Maeda, K.

Yokota, M.

Kido, J. ^{[7
]}

Nagata, T. ^{[7
]}

Kurihara, H. ^{[8
]}

Takashiba, S. ^{[9
]}

Sibutani, T.

Fukuda, M.

Noguchi, T.

Yamazaki, K. ^{[10
]}

Yoshie, H. ^{[10
]}

Ioroi, K.

Arai, T. ^{[11
]}

Nakagawa, T. ^{[12
]}

Ito, K. ^{[13
]}

Oda, S. ^{[14
]}

Izumi, Y. ^{[14
]}

Ogata, Y.

Yamada, S. ^{[2
,15
]}

Shimauchi, H. ^{[16
]}

Kunimatsu, K.

Kawanami, M.

Fujii, T.

Furuichi, Y.

Furuuchi, T. ^{[17
]}

Sasano, T. ^{[17
]}

Imai, E. ^{[18
]}

Omae, M. ^{[19
]}

Yamada, S. ^{[2
,15
]}

Watanuki, M.

Murakami, S. ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Dent, Dept Periodontol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dent Hosp, Dept Periodontol, Div Oral Biol & Dis Control, Suita, Osaka 5650871, Japan

[3] Kagoshima Univ, Dent Hosp, Dept Periodontol, Kagoshima 890, Japan

[4] Nagasaki Univ Hosp, Attached Sch Dent, Dept Periodontol, Nagasaki, Japan

[5] Med & Dent Hosp, Fukuoka Dent Coll, Dept Odontol, Sect Periodontol, Fukuoka, Japan

[6] Med & Dent Hosp, Fukuoka Dent Coll, Dept Gen Dent, Sect Gen Dent, Fukuoka, Japan

[7] Tokushima Univ Hosp, Dept Periodontol & Endodontol, Tokushima, Japan

[8] Hiroshima Univ Hosp, Dept Periodontal Med, Div Frontier Med Sci, Hiroshima, Japan

[9] Okayama Univ Hosp, Dept Pathophysiol, Okayama, Japan

[10] Niigata Univ, Med & Dent Hosp, Dept Oral Biol Sci, Div Periodontol, Niigata 95021, Japan

[11] Tsurumi Univ, Dent Hosp, Dept Periodont & Endodont, Yokohama, Kanagawa, Japan

[12] Keio Univ Hosp, Dept Dent & Oral Surg, Keio, Japan

[13] Nihon Univ, Sch Dent, Dent Hosp, Dept Periodontol, Tokyo 102, Japan

[14] Tokyo Med & Dent Univ, Univ Hosp, Fac Dent, Sect Periodontol,Dept Hard Tissue Engn, Tokyo, Japan

[15] Chiba Hosp, Tokyo Dent Coll, Dept Periodontol, Chiba, Japan

[16] Tohoku Univ Hosp, Dept Oral Biol, Div Periodontol & Endodontol, Sendai, Miyagi, Japan

[17] Tohoku Univ, Grad Sch Dent, Dept Oral Med & Surg, Div Oral Diag, Sendai, Miyagi 980, Japan

[18] Nagoya Univ, Grad Sch Med, Dept Nephrol, Nagoya, Aichi 4648601, Japan

[19] Izumisano Municipal Hosp, Rinku Gen Med Ctr, Dept Oral & Maxillofacial Surg, Izumisano, Japan

来源：

JOURNAL OF DENTAL RESEARCH | 2011年 / 90卷 / 01期

关键词：

periodontitis; tissue regeneration; fibroblast growth factor-2; LIGAMENT CELLS; INTRABONY DEFECTS; ATTACHMENT; BFGF; DOGS;

D O I：

10.1177/0022034510384616

中图分类号：

R78 [口腔科学];

学科分类号：

100302 [口腔临床医学];

摘要：

The efficacy of the local application of recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. Modified Widman periodontal surgery was performed, during which 200 mu L of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis.

引用

页码：35 / 40

页数：6

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