B cells and immunosenescence: A focus on IgG+IgD-CD27- (DN) B cells in aged humans

被引：74

作者：

Bulati, Matteo ^{[1
]}

Buffa, Silvio ^{[1
]}

Candore, Giuseppina ^{[1
]}

Caruso, Calogero ^{[1
]}

Dunn-Walters, Deborah K. ^{[2
]}

Pellicano, Mariavaleria ^{[1
]}

Wu, Yu-Chang ^{[2
]}

Romano, Giuseppina Colonna ^{[1
]}

机构：

[1] Univ Palermo, Immunosenescence Unit, Dept Pathobiol & Med & Forens Biotechnol, I-90134 Palermo, Italy

[2] Kings Coll London, Sch Med, Dept Immunobiol, London WC2R 2LS, England

来源：

AGEING RESEARCH REVIEWS | 2011年 / 10卷 / 02期

关键词：

Immunosenescence; Memory B lymphocytes; Centenarian offspring; Alzheimer's disease; CD8(+) T-CELLS; CC-CHEMOKINE RECEPTOR-5; IG CLASS SWITCH; IMMUNE-RESPONSE; ALZHEIMERS-DISEASE; PLASMA-CELLS; PNEUMOCOCCAL POLYSACCHARIDE-4; PHOSPHORYLCHOLINE-ANTIBODY; REPERTOIRE DIVERSITY; CYTOKINE PRODUCTION;

D O I：

10.1016/j.arr.2010.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG(+)IgD(-)CD27(-)) that we have demonstrated is increased in healthy elderly. (C) 2010 Elsevier B.V. All rights reserved.

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收藏

页码：274 / 284

页数：11

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