Chemistry of epoxysulfones:: A new route to polyhydroxylated pyrrolidines

被引:23
作者
Díez, D [1 ]
Benéitez, MT [1 ]
Gil, MJ [1 ]
Moro, RF [1 ]
Marcos, IS [1 ]
Garrido, NM [1 ]
Basabe, P [1 ]
Urones, JG [1 ]
机构
[1] Univ Salamanca, Fac Ciencias Quim, Dept Quim Organ, E-37008 Salamanca, Spain
来源
SYNTHESIS-STUTTGART | 2005年 / 04期
关键词
epoxysulfones; iminosugars; 1,4-dideoxy-1,4-imino-D-lyxitol; 1,4-dideoxy-1,4-imino-D-mannitol;
D O I
10.1055/s-2005-861792
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new methodology for the synthesis of polyhydroxylated pyrrolidines using epoxysulfones is described. The synthesis of two natural glycosidase inhibitors, 1,4-dideoxy-1,4-imino-D-lyxitol and 1,4-dideoxy-1,4-imino-D-mannitol (DIM), is reported.
引用
收藏
页码:565 / 568
页数:4
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